Artesunate for Injection is indicated for the initial treatment of severe malaria in adult and pediatric patients. Treatment of severe malaria with Artesunate for Injection should always be followed by a complete treatment course of an appropriate oral antimalarial regimen see Dosage.
Artesunate is metabolized to the active DHA. the Endoperoxide bridge of DHA reacts with Heme, generating free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites during all Erythrocytic stages.
